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It is hard to know the true risk without adequate safety trials
Protandim marketed by LifeVantage Corporation, is a nutritional supplement comprised of five plant extracts (milk thistle, bacopa, ashwagandha root, turmeric, green tea) that supposedly activates the Nuclear factor (erythroid-derived 2)-like 2, (called Nrf2) transcription factor pathway that is integral to several antioxidant enzymes, including -glutamyl cysteine synthase (an enzyme that catalyzes the committed step in glutathione synthesis) [14]
These findings support the hypothesis that the experimental LC supplementation protocol is more effective than the traditional "classic" protocol in improving endurance performance through enhanced fat oxidation, more efficient cardiovascular function, and reduced perceived exertion